**Artificial exosensory dysphoria** ---- **Artificial exosensory dysphoria** (AExD) is a psychological condition characterized by cognitive and emotional distress arising from prolonged neural interfacing with artificial sensory systems. It is most commonly observed in mobile fencer pilots who rely extensively on brain-computer interfaces (BCIs) to operate, where a neural uplink to complex artificial sensory arrays is involved that enhance visual and auditory perception. This uplink extends clarity, spectrum, and spatial awareness. Over an extended period of time, the brain adapts to these augmented inputs. Sudden disconnection from the BCI can, however, trigger a dysphoric state marked by anxiety, depression, and paranoia. Without therapeutic intervention and cognitive retraining, the brain misinterprets the disconnection as the loss of a fundamental part of itself, potentially escalating into severe psychological distress or suicidality. AExD presents in two forms: **chronic** and **acute**. Chronic AExD develops after prolonged, uninterrupted exposure to artificial sensory input. Upon disconnection, the brain experiences a pronounced sense of loss, often accompanied by symptoms such as persistent anxiety, depression, and cognitive fatigue. Acute AExD, on the other hand, results from repeated and rapid transitions between connection and disconnection referred to as "neural whiplash". This pattern confuses the brain’s perceptual baselines, leading to disorientation, sensory dysesthesias, nausea, and distortions in auditory and visual perception. AExD may also affect individuals who have suffered prior organic limb loss. BCIs can restimulate the brain's motor functions by allowing such users to control artificial limbs, like a fencer’s arms or legs, via neural synchronization. However, reactivation of dormant motor circuits provoke intense phantom sensations upon disconnection, accompanied by emotional distress such as anxiety or depression stemming from the renewed perception of lost bodily integrity. {{tag>biology_and_nature medicine}}